How many neutrophils are enough (redux, redux)?

نویسندگان

  • Samuel C Silverstein
  • Raul Rabadan
چکیده

Many chemotherapeutic regimens produce neutropenia, which predisposes to microbial infection. However, not all neutropenic individuals develop infections, so the ability to predict this outcome would be a powerful clinical tool. In this issue of the JCI, Malka et al. describe a dynamic system model of neutrophil bactericidal activity that confirms and extends the concept of critical neutrophil concentration. The authors demonstrate that when the neutrophil concentration approaches the critical concentration, bacterial populations in contact with them exhibit bistability. Their experimental findings raise the intriguing possibility of greater variability in bactericidal activity of neutrophils from healthy adults than heretofore recognized; their model predicts that this could have life-and-death consequences.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Redux 0 Server

Redux 0 is a subset of the full REDUX modell7]. The latter performs problem solving. In contrast Redux 0 does not and acts only as a decision maintenance server. It takes objects of types deened in an ontology of decision components and maintains dependencies between them. Redux 0 is domain-independent. The dependency relationships are maintained on the basis of proposition type and not content...

متن کامل

Birkhoff for Lovelock Redux

We show succinctly that all metric theories with second order field equations obey Birkhoff's theorem: their spherically symmetric solutions are static.

متن کامل

Pseudo-chancre Redux with Negative Serology. a Case Report.

Pseudo-chancre redux is rare and is defined as a gummatous (tertiary stage) recurrence at the site of the primary chancre (Stokes, Beerman, and Ingraham, 1944). The condition must be distinguished clinically and nosologically from chancre redux (monorecidive), which is an infectious relapse during the early phase of syphilis, at the site of the original chancre, from which treponemes may be rec...

متن کامل

Cybernetics, Redux: An Outside-In Strategy for Unraveling Cellular Function.

A new paper in Science reveals how repetitive stimulation can identify and help to repair fragilities within a signaling network, while using linear mathematical models inspired by engineering, thereby suggesting how cybernetic methods can be integrated into systems and synthetic biology.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The Journal of clinical investigation

دوره 122 8  شماره 

صفحات  -

تاریخ انتشار 2012